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What is ALDH2 Deficiency and Why is it Important?

What is ALDH2 Deficiency and Why is it Important?

Explanation of ALDH2 Deficiency

Delta Nutrassentials founder Spencer Gordon (UC Berkeley - Molecular Biology and Human Metabolism) explains ALDH2 Deficiency, what it is, and why it is important.

 

ALDH2 Deficiency is a genetic mutation that leaves people unable to properly metabolize a toxic carcinogen called Acetaldehyde. The simplest way for someone to know if they have ALDH2 Deficiency is if they experience Alcohol Flush Reaction or very red flushing of the face and skin when they drink alcohol.

 

Acetaldehyde is a very reactive compound and it can cause damage to our proteins and DNA. Small amounts of Acetaldehyde are constantly circulating in the blood.

 

Because people with ALDH2 Deficiency can’t metabolize Acetaldehyde properly, it is constantly present in higher than normal concentrations in their body, which has very serious long term health implications.

 

Individuals with ALDH2 Deficiency are at significantly increased risk of getting gastric cancer, esophageal cancer and liver cirrhosis. This is due to the long term continual exposure to Acetaldehyde.